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I’ve spent a very pleasant evening in the company of the Sceptics in the Pub London, where the speaker was Dr. Aubrey de Gray, Chief Scientific Officer with the SENS Foundation. In brief, de Gray (Wikipedia article) set out the work of the SENS foundation which, as I understand it, looks at ageing as a disease which it then sets out to cure as a problem of regenerative medicine. While that is the primary aim, it has the effect, if successful, of increasing both quality and quantity of life; that is to say, making something approaching immortality not only possible but desirable.

De Gray set out a paradigm whereby metabolism causes damage, and damage then causes pathology. In this model, gerontology attempts to intervene in the first step – problematic because of the great complexity of metabolism – and geriatrics intervenes in the first step – problematic because damage has already caused pathology and is at best palliative. He sought to reverse accumulated damage before it became pathological.

Initially, this would allow for an extension of the useful human lifespan by perhaps thirty years. Once that first step was accomplished, refinements in technique would allow, excepting being hit by cars and so on, to continue for arbitrarily long periods, through the possibility of increasingly eficacious treatments before the eficacy of repeated cycles of previous treatments lost eficacy.

You can get a flavour of his speech from this TED talk.

Broadly, I would raise three problems with de Gray’s plan.

Firstly, the scientific. I can’t assess his science, but a number of people there raised fairly substantial problems with his paradigm and with the conclusions he drew from it. That is probably one for the peer reviewed papers.

Secondly, the technological. The very long, four-figure lifespans suggested depended not just on continuing improvements in the (speculative) set of technologies, bit that those improvements happened faster than people died because of a loss of eficacy as described above. The examples de Gray cited in support of his position were the motor car and the aeroplane. Unfortunately for him, the equally plausible alternative of the jet pack was raised: theoretically possible, desirable even, and can be turned into a prototype that can fly for half a minute, but can’t be turned into a production model (because the amount of fuel that can be loaded onto a human is finite and less than what’s needed for useful flight). Another example would be power from nuclear fusion, which has been ten years away for fifty years. It is a prediction based on little more than fiat.

Thirdly, the socio-economic. In answer to a question from yours truly about the cost of the treatments, de Gray was quick to observe, thousand-year life spans would have major effects on world society, meaning that we could throw much of traditional economics out of the window. If we do that, though, we throw political economy out of the window. Thus, de Gray’s assetion that the state would pay for its citizens to have these treatments is distinctly problematic as the state, as we know it, would not necessarily sill exist. Even if we accept that the state still exists in a recognisable form and that it makes economic sense for states to pay for these treatments, it does not follow that they will pay for them. As de Gray thought equality was a major issue, it’s worth going into at slightly greater length.

The basis from which de Grey works is that regenerative medicine is medicine like any other, albeit with remarkable effects. As we know from the current debate in the US, there are plenty of people who see taking money from them to pay for the healthcare of others as morally wrong. There are also plenty of countries that would like to provide comprehensive healthcare, but cannot afford it. De Grey provided no explanation of how we would roll out this treatment when we cannot at the moment give people with economic potential very cheap drugs – say, hydration salts for diarrhea – that would have similar economic benefits to the de Grey treatments but at vastly lower costs per dose. From the point of view of the state, it doesn’t matter whether a day’s work is done by a thirty-year-old or a three hundred and thirty-year-old. Given that states do not have to provide pensions or old age healthcare now, and that the mechanism by which they will be convinced to do so is absent, it seems as reasonable to conclude that arbitrarily long lives will remain the province of the wealthy as to conclude that we will enter this brave, new world. A nightmare scenario would be lots of people having access to these treatments but not making the necessary lifestyle changes. If we kept dropping kids every twenty or thirty years over a thousand year life, we’d very quickly overpopulate the planet.

I hope that de Gray’s science is more thorough than his statecraft.

Of course, if de Gray is right, I look forward to seeing you at the February 2317 meeting of Sceptics in the Pub London – assuming someone hasn’t already booked the room.

xD.